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Polarean Technology Used in Severe Asthma Study

Polarean Imaging plc (AIM: POLX), the medical-imaging technology company, with a proprietary drug-device combination product for the magnetic resonance imaging (MRI) market, notes the publication of a study using Polarean's hyperpolarised gas MRI technology in a study of patients with severe asthma in the April edition of the American Journal of Respiratory and Critical Care Medicine (AJRCCM).

The study, entitled "Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma" is authored by Svenningsen, Eddy, Lim, Cox, Nair and Parraga and can be obtained from the AJRCCM website.

The study looked at patients with severe asthma and investigated the contributions of both inflammatory and non-inflammatory components of airway disease. A key finding was that MRI scans using hyperpolarized gas were able to identify, for the first time, the airway inflammatory (eosinophilia) and non-inflammatory contributions (smooth muscle dysfunction) to ventilation heterogeneity in patients with severe asthma.

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Researchers at Hanover Medical School (Germany) in collaboration with Fraunhofer Institute of Toxicology and Experimental Medicine have started utilizing unique capabilities of hyperpolarized xenon for pulmonary gas exchange imaging in various lung research projects. Hanover Medical School is part of the Biomedical Research in Endstage and Obstructive Lung Disease, Hanover (BREATH) research network, one of the five sites of the German Centre for Lung Research (DZL). Wacker calls it ‘an ideal set-up which offers perfect synergies’.

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